Novel roles for RNA in Biology and Therapy

 

GENERAL DIRECTOR:

Roger Kornberg, Stanford University

 

ORGANIZER:

Ruth Sperling, The Hebrew University of Jerusalem

 

 

Lecture Recordings

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Program

Israeli RNA Society Meeting

 

 

Research during recent decades has identified RNA molecules as key players in biology and medicine. Novel types of large and small RNAs, and novel roles for RNA molecules, not only as informational molecules, but also as enzymes and as regulators of gene expression, have emerged. RNA processing and alternative splicing, major contributors to proteome versatility, play crucial roles in cell identity and development.  RNA molecules serve as catalysts and as regulators of chromatin structure, gene expression at different levels, and protein function in diverse pathways. The involvement of RNA molecules in disease-related processes has led to RNA-mediated therapies. For example, manipulation of alternative splicing and gene expression by antisense RNAs enabled breakthroughs in the therapies of rare disease, and mRNA-based vaccines have played a crucial role in the fight against the COVID-19 pandemic. Many challenges lie ahead in deciphering the structure and function of RNA molecules and in the development of additional RNA-based therapies. The RNA School will bring together many of the scientists responsible for the important discoveries, and will support stimulating and fruitful discussions of the major topics.    

As part of the school, we will hold the Israeli RNA Society meeting in memory of Prof. Yossi Sperling on 26 October.

 

SPEAKERS:

Gil Ast, Tel Aviv University
Maria Carmo-Fonseca, University of Lisbon
Chonghui Cheng, Baylor College of Medicine
Matthias W. Hentze, European Molecular Biology Laboratory
Eran Hornstein, Weizmann Institute of Science
Batsheva Kerem, The Hebrew University of Jerusalem
Adrian R. Krainer, Cold Spring Harbor Laboratories
Erez Levanon, Bar-Ilan University
Reinhard Lührmann, Max-Planck-Institute for Biophysical Chemistry
Yael Mandel-Gutfreund, Technion
Lynne E. Maquat, University of Rochester Medical Center
Hanah Margalit, The Hebrew University of Jerusalem
Shulamit Michaeli, Bar-Ilan University
Gideon Rechavi, Sheba Medical Center & Tel Aviv University
Michal Shapira, Ben-Gurion University of the Negev
Yaron Shav-Tal, Bar-Ilan University
Noam Stern-Ginossar, Weizmann Institute of Science
Yehuda Tzfati, The Hebrew University of Jerusalem
Igor Ulitsky, Weizmann Institute of Science
Ada Yonath, Weizmann Institute of Science