Research Groups:Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires: an Example of Multi-Cellular Co-Operation

[RG # 150]  Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires: an Example of Multi-Cellular Co-Operation

March 26- June 30, 2017

Organizers: 
Uri Hershberg  (Drexel University)
Gur Yaari (Bar-Ilan University)

We propose to study the general problems of functionality and robustness in complex biological systems, through a focus on the adaptive immune response as a model system. The adaptive immune response is a complex system, which comprises many interacting cells that are subject to various sources of stochasticity. We will address fundamental questions in the field such as how B and T cell repertoires collectively go through a process of stochastic diversity generation and clonal selection, and consistently yield functional controlled immune responses in a noisy environment. This understanding will be important in developing control strategies to modulate the immune response (e.g., with vaccinations or immune therapies) since, while predictable in the aggregate, human immune responses can display marked variability. For example, a small fraction of individuals do not raise antibodies following influenza vaccination, and efficacy rates for vaccination in older individuals are generally under 30%. Infections with West Nile virus are usually asymptomatic, but some patients experience severe neurological disease and even death. The potential role of stochasticity at different spatial and temporal scales in driving these diverse yet robus responses will be a main focus of our research group.

 

Mini Symposium Series

1st Mini Symposium Series on Stochasticity and Control in Biological Systems> 

2nd Mini Symposium Series on Stochasticity and Control in Biological Systems>

 

 

Members

andrew

Andrew Collins

FELLOW
University of New South Wales
Andrew Collins is an Associate Professor in the School of Biotechnology and Biomolecular Sciences at the University of New South Wales.
sol

Sol Efroni

FELLOW
Bar-Ilan University
Sol Efroni is a Professor in Systems Biomedicine Lab at Bar-Ilan University. His research focuses on systems biology.
nir

Nir Friedman

FELLOW
Weizmann Institute
Nir Friedman is a Professor in Department of Immunology at Weizmann Institute of Science. His research focuses on systems immunology of T cells.
gartenhaus

Ronald Gartenhaus

FELLOW
University of Maryland
Ronald B. Gartenhaus is a Professor in School of Medicine at the University of Maryland.
hershberg

Uri Hershberg

FELLOW
Drexel University
Uri Hershberg is an Associate Professor at the School of Biomedical Engineering, Science and Health Systems and the Department of Immunology and Microbiology …
michal

Michal Or-Guil

FELLOW
Humboldt University
Michal Or-Guil is a Professor in the Department of Biology at Humboldt University.
gur

Gur Yaari

FELLOW
Bar-Ilan University
Gur Yaari is a Professor in the Faculty of Engineering at Bar-Ilan University.

Events

Stochasticity

Batsheva de Rothschild Seminar on: Stochasticity and Control in the Dynamics and Diversity of Immune Repertoires

Sun, 18/06/2017 to Fri, 23/06/2017

Group Conference

 

Organizers:

Uri Hershberg (Drexel University)
Gur Yaari (Bar-Ilan University)
Nir Friedman (Weizmann Institiute)
Sol Efroni (Bar-Ilan University)
Tomer Hertz (Ben Gurion University)

 

Program >

Abstract booklet >